Ebook Crystallography Made Crystal Clear Second Edition A Guide for Users of Macromolecular Models (Complementary Science)


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Macromolecules are the proteins and nucleic acids upon which life depends. Understanding the action of biological macromolecules (giant molecules) requires detailed knowledge of their structures. Most of the more than ten thousand known structures of protein and nucleic acids were obtained by x-ray crystallography, the standard mechanism for determining protein structure. Essentially, proteins are frozen into rigid crystals, which can be stacked up in a repeating pattern--like supermarket displays. The structure of each individual crystal can be determined by the way x-rays are bent when they pass through the composite crystal. Protein structure is essential when investigating protein interactions and planning drug development. Crystallography Made Crystal Clear, Second Edition explains how scientists discover the structures of the macromolecules. Scientists do not see these molecules directly. Instead, they build models as a means of interpreting data from x-ray diffraction by crystals, or by irradiation by other forms of energy. Users of these models need to know how they are obtained in order to know what they are seeing when they study a model of a macromolecule. They also need to know how to judge whether conclusions they draw from the molecular models are really supported by the models. This book uses visual and geometric models to help readers understand the mathematics that forms the basis of x-ray crystallography.The field of protein crystallography is growing every day and has been instrumental in discovering the molecular principles of biology and in discovering new drugs, such as the recent protease inhibitors for AIDS. The field includes the largest percentage of Nobel prizes than any other scientific discipline. Every major university and drug company has a protein crystallography laboratory and this book is an invaluable aid to those wishing to practice protein crystallographyor just learn more about how it is actually done. Key Features* Provides clear, understandable descriptions of principles of X-ray crystallography* Leads reader through unintimidating and thorough explanations of the underlying mathematics * Provides abundant illustrations, including diagrams, charts, photographs, and color stereo* images* Explains how to read crystallography papers in research journals* Includes brief descriptions of other diffraction methods (neutron, electron, Laue) and the kinds* of structural information they can provide* Introduces other methods of macromolecular structure determination (NMR spectroscopy and* homology modeling), and provides guidance in judging the quality of these models Electrochemical Glucose Sensors and Their Applications in Biography Adam Heller was born in 1933 Surviving the Holocaust he arrived in Israel in 1945 He received his MSc in Chemistry and Physics in 1957 then his PhD RasMol V275 Manual - RasMol and OpenRasMol Author Item Language Isabel Servn Martnez Jos Miguel Fernndez Fernndez 26 Manual: Spanish Jos Miguel Fernndez Fernndez: 271 Manual substancial - Scribd the of in a and is to was it for that are as he on by s with from or this they be an at his not also has were which have people one can but there META-INF/MANIFESTMFname/audet/samuel/shorttyping META-INF/MANIFESTMFname/audet/samuel/shorttyping/ShortDictManager$BufferedStreamclassname/audet/samuel/shorttyping/ShortDictManagerclassname/audet/samuel Biopython Tutorial and Cookbook Biopython Tutorial and Cookbook Jeff Chang Brad Chapman Iddo Friedberg Thomas Hamelryck Michiel de Hoon Peter Cock Tiago Antao Eric Talevich Bartek Wilczy& NanoTemper Technologies GmbH: Monolith NT115 Series The Monolith NT115 combines the versatility to use of a broad range of fluorophores and fluorescent proteins with all benefits of the MicroScale Thermophoresis PHARMACEUTICAL MANUFACTURING HANDBOOK Production and Processes SHAYNE COX GAD PHD DABT Gad Consulting Services Cary North Carolina CONTRIBUTORS Le Live Marseille : aller dans les plus grandes soires Retrouvez toutes les discothque Marseille et se retrouver dans les plus grandes soires en discothque Marseille Online Exhibitor Planner - Pittcon An ISO 9001 certified company designs and manufactures a complete line of viscometers electronic balances scales weighing indicators and controllers for pharmacy - - CRC Press/Balkema2014 181 p
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